6 September 2022 - - Iceland-based clinical-stage biopharmaceutical company EpiEndo Pharmaceuticals has received regulatory and ethics approval to commence a Lipopolysaccharide challenge clinical trial with lead molecule EP395, the company said.

EP395 is an orally available macrolide or 'Barriolide' with reduced antimicrobial activity which aims to address the unmet medical need for a treatment for COPD (Chronic Obstructive Pulmonary Disease).

The study will be conducted in up to 48 healthy adults at the Hannover Medical School in Germany. The Principal Investigator is Professor Jens Hohlfeld, director of Airway Research and Aerosol Medicine at the Fraunhofer Institute for Toxicology and Experimental Medicine.

This proof of pharmacology study is designed to assess the effect of repeat oral doses of EP395 on inflammation in the lung induced by inhaled LPS.

The results of the study will give key data on the anti-inflammatory effects of EP395. For more information on the study, see ClinicalTrials.gov (NCT05516316).

EpiEndo said it takes a novel approach to drug development for chronic respiratory diseases, focusing on using its Barriolide compounds to enhance the integrity of the epithelial cell layer in the lung to reduce disease-causing inflammation.