Additional in vitro data show that SLV213 greatly enhances the efficacy of remdesivir and molnupiravir, two drugs that target the virus.
These data will be presented at the 40th annual meeting of the American Society of Virology taking place virtually July 19-23.
Remdesivir and molnupiravir act once the virus is inside of the cell, starving it of the nucleic acids required for it to replicate. Similar to monoclonal antibodies, SLV-213 inhibits the activation of the spike protein required for SARS-CoV-2 to infect a cell.
Whereas monoclonal antibodies and nucleoside analogs act specifically on the virus, SLV213 blocks the human cell entry pathway to broadly be effective against SARS-CoV-2 and its variants as well as other coronaviruses and viruses, including Ebola and Nipah.
As an oral host-acting antiviral, SLV213 has the potential to be used together with direct-acting antivirals or alone as a prophylactic or outpatient treatment, a preferred setting for mild to moderate and asymptomatic patients.
At ASV 2021, Selva will present data showing SLV213 protected lungs against damage when given as a therapeutic or a prophylactic in a nonhuman primate model, compared to untreated controls.
In additional preclinical studies in a NHP model, SLV213 demonstrated dose-dependent lung protection and reductions in viral load in treated animals compared to non-treated controls.
Furthermore, previously disclosed preclinical data show SLV213 is equipotent against prominent SARS-CoV-2 variants: Alpha (B.1.1.7 or UK), Beta (B.1.351 or South Africa), and Gamma (P.1 or Brazil). Selva successfully completed a Phase 1 ascending oral dose clinical trial of SLV213 in healthy subjects.
In that study, SLV213 was shown to be safe and well-tolerated at all dose levels tested. SLV213 is ready to enter a Phase 2 clinical trial for outpatient antiviral treatment of COVID-19 patients.
SLV213 is a novel, orally available, small molecule antiviral investigational drug that inhibits human host cell cysteine proteases to block viral entry.
In addition to being developed as a treatment for SARS-CoV-2 (COVID-19), SLV213 has demonstrated in vitro broad antiviral activity against coronaviruses, Ebola viruses, and Nipah viruses.
SLV213 has also completed preclinical development as a potential therapy against Chagas disease, a parasitic disease endemic to South and Central America and spreading into the southern United States.
SLV213 was developed based on research from UC San Diego, and the university exclusively licensed it to Selva Therapeutics.
Selva Therapeutics is a privately held biotechnology company dedicated to the development of therapeutics for infectious diseases. By rapidly developing SLV213 for COVID-19, Selva Therapeutics intends to bring a valuable treatment to the market that has the potential to fight multiple life-threatening infectious diseases.
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