Therapy Areas: Central Nervous System
Alzheimer's Association announces COVID-19 infection associated with an increase in Alzheimer's biomarkers & long-term cognitive dysfunction
30 July 2021 -

Alzheimer's Association reported on Thursday a link between COVID-19 and persistent cognitive deficits, including acceleration of the pathology and symptoms of Alzheimer's disease, as well as the virus's long-term respiratory and gastrointestinal symptoms, based on the new research reported at the 2021 Alzheimer's Association International Conference (AAIC) held in Denver, Colorado.

The association added that the participants were studied three to six months after COVID-19 infection. More than half had persistent problems with forgetting and about one in four experienced additional problems with cognition, including language and executive dysfunction. These difficulties were associated with persistent problems with the sense of smell, but not with the severity of the original COVID-19.

In some people, these neurological symptoms persist and researchers are working to understand the mechanisms by which this brain dysfunction occurs and what that means for long-term cognitive health, revealed the association.

Additionally, Alzheimer's Association and the World Health Organization (WHO), who are part of an international, multidisciplinary consortium focused on collecting and evaluating the long-term consequences of COVID-19 in the central nervous system, as well as differences between countries, presented the data at the AAIC 2021 in Greece and Argentina. The team suggested that older adults often suffer from lasting cognitive decline, including persistent lack of smell, after recovering from SARS-CoV-2 infection.

Also at the AAIC 2021, the team presented data that states biological markers of brain damage, neuroinflammation and Alzheimer's are closely correlated with the presence of neurological symptoms in COVID-19 patients. Individuals who experienced cognitive decline after COVID-19 infection were more likely to have low blood oxygen after brief physical exertion, as well as poor general fitness.

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