Therapy Areas: Cardiovascular
COVID-19 Patients with Both Type 2 Diabetes and Heart Disease Have Greater Risk of Death
6 June 2022 - - COVID-19 patients with both type 2 diabetes mellitus and cardiovascular disease showed significantly higher rates of mortality, intensive care unit admissions, and hospitalizations compared to COVID-19 patients with neither T2DM nor CVD, according to the a recent study.

The study, by HealthCore, Inc., Boehringer Ingelheim and Anthem, Inc. soon to be Elevance Health on June 28 -- also found the cost per patient was higher in COVID-19 patients with T2DM and CVD compared to individuals without either disease.

The findings were presented at the American Diabetes Association Scientific Sessions 2022 in New Orleans.

This observational study compared clinical and economic outcomes of COVID-19 patients with and without T2DM and CVD. Researchers used existing claims and lab data from the HealthCore Integrated Research Database (HIRD) of commercially insured and Medicare patients with COVID-19 between March 1, 2020 and May 31, 2021.

Patients were grouped by those having no T2DM or CVD, having T2DM only, and having both T2DM and CVD.

The primary outcomes included hospital/ICU admission and mortality following COVID-19 infection.

Propensity score matching and multivariable analyses were performed. After matching, 6,967 patients were identified for each group with a mean follow-up of 5.4 months.

A greater percentage of patients with T2DM and CVD had at least one COVID-19-related hospitalization compared to COVID-19 patients without T2DM or CVD (27.7% vs. 17.3%).

Patients with T2DM and CVD also had a 26% higher mortality rate, were 59% more likely to be hospitalized, and 74% more likely to be admitted to the ICU after accounting for baseline differences between cohorts. In this analysis, the increased utilization of healthcare resources contributed to higher costs.

Researchers found that COVID-19 patients with T2DM and CVD had higher mean COVID-19-related healthcare costs per month after COVID-19 infection compared to COVID-19 patients without either condition (USD 9,290 vs. USD 5,498).

The study also showed that COVID-19 patients with T2DM only used the healthcare system more than COVID-19 patients without T2DM or CVD, but not as much as individuals with both conditions.

Compared to patients with no T2DM or CVD, patients with T2DM only were 28% more likely to be hospitalized and 32% more likely to be admitted to the ICU after accounting for baseline differences between cohorts.

No significant difference was observed between those with COVID-19 with T2DM only and those without T2DM or CVD in terms of survival. In terms of healthcare costs, COVID-19 patients with T2DM had higher mean costs than patients without either T2DM or CVD (USD 6,091 vs. USD 5,498).

This study is the most recent work coming out of the large-scale research collaboration between Anthem, Inc., Boehringer Ingelheim, and HealthCore, Inc. to generate real-world evidence to help inform the development of new medicines, standard of care, and interventions.

In 2014, Anthem, Inc., Boehringer Ingelheim, and HealthCore Inc. commenced a research project to identify and address unmet medical needs across populations of mutual interest.

The collaboration enables the companies to generate real-world evidence and develop health economic and outcomes data to inform the development and evaluation of new medicines, standard of care, and interventions.

Together, the companies are exploring issues related to appropriate use of existing and new therapies and interventions and the impact these have on clinical and economic outcomes that matter the most to patients.

The company is a wholly owned, independently operating subsidiary of Anthem, Inc.

Boehringer Ingelheim was founded in 1885 and family-owned ever since.

Anthem, which will become Elevance Health on June 28, 2022 is a health company dedicated to.

Through its affiliated companies, Anthem serves approximately 118m people, including nearly 47m within its family of health plans.
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