Allorion Therapeutics, a US and China-based biotechnology company that focuses on the discovery of new small molecule drugs for treating cancer and autoimmune diseases, announced on Tuesday that it has signed an exclusive option and global license agreement with AstraZeneca (LSE/STO/Nasdaq: AZN), an Anglo-Swedish multinational pharmaceutical and biotechnology company.
The option and global license agreement has been signed to develop and commercialise a novel epidermal growth factor receptor (EGFR) L858R mutated allosteric inhibitor, as a potential new treatment for advanced EGFR-mutant non-small cell lung cancer (NSCLC).
Under the terms of the agreement, AstraZeneca will be granted an exclusive option to license a novel EGFR L858R allosteric inhibitor to develop and commercialize globally. Allorion is eligible to receive upfront and near-term payments of up to USD40m, and additional development and commercial milestone payments of over USD500m, as well as tiered royalties on net sales worldwide.
Fang Li, PhD, Allorion cofounder and chief scientific officer, said: "Allorion's EGFR L858R allosteric inhibitor is designed to address mechanisms of resistance to current EGFR inhibitors and has the potential to enhance their activity, when used in combination. We are excited to enter into this agreement with AstraZeneca, a global leader in this field, to advance our EGFR inhibitor into the clinic and explore potential combinations with other EGFR targeting molecules such as Tagrisso."
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