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Nashville Biosciences, Illumina Ink Agreement to Establish Preeminent Clinico-Genomic Resource for Life Sciences Research and Development
14 January 2022 - - US-based Nashville Biosciences, a wholly-owned subsidiary of Vanderbilt University Medical Center, has inked an agreement with US-based genomic technology company Illumina (NASDAQ: ILMN) to realize the full potential of VUMC's DNA databank, BioVU, the company said.

The agreement is a continuation of Vanderbilt's long-term effort around BioVU and will accelerate genomic sequencing, resulting in new discoveries to advance new methods for diagnosing, preventing and treating an array of human diseases.

Under the terms of the agreement, Nashville Biosciences and Illumina will seek to establish an alliance with multiple pharmaceutical industry partners to perform whole genome sequencing on approximately 250,000 de-identified DNA samples collected under an Institutional Review Board -approved process over the past 15 years.

The resulting library of de-identified health and genomic data, collected from patients diverse in gender, race, age and clinical conditions will be available to industry partners and researchers at Vanderbilt to discover and advance new methods for diagnosing and treating an array of human diseases.

BioVU is the most comprehensive collection of human DNA and other biological materials stored at a single site.

DNA samples are extracted from discarded blood collected at VUMC during routine clinical testing and linked to a "synthetic derivative" a copy of VUMC's electronic medical records from which patients' personal identifying information has been removed while still preserving the clinical information generated in the ongoing delivery of healthcare.

The linking of specific DNA sequences to clinical information has enabled researchers to understand a wide range of health conditions, from cancer to heart disease, as well as genetic factors that increase the risk for severe illness following infections, including COVID-19.

Nashville Biosciences is a clinical and genomic analytics company providing access to VUMC's research resources, notably BioVU, and is helping biopharmaceutical, diagnostics, and other life sciences partners accelerate their R and D activities.

Since its founding in 2018, Nashville Biosciences has partnered with more than 60 clients to utilize BioVU to identify new disease biomarkers and potential drug targets, optimize clinical trials and conduct other studies using real-world data.

In 2016, for example, VUMC researchers and Illumina collaborated to analyze approximately 100,000 BioVU DNA samples using Illumina's Multi-Ethnic Genotyping Array.

At the time, it was the largest single use of the MEGA array and has provided BioVU researchers a rich platform for genetic discovery since its completion.

Nashville Biosciences, a wholly-owned subsidiary of Vanderbilt University Medical Center, was created to harness the Medical Center's extensive genomic and bioinformatics resources for drug and diagnostics discovery and development.

Leveraging Vanderbilt University innovation, Nashville Biosciences serves as a commercial interface between outside companies and the formidable research capabilities housed within VUMC, including BioVU, one of the world's most comprehensive genetic databases linked to de-identified medical records with years of longitudinal clinical data.

This unique asset is one of the largest and highest quality of its kind, providing an opportunity to guide R and D activity in biotech, pharma, diagnostics, medical devices and other life sciences applications.
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