Policy & Regulation
PsiOxus Therapeutics Updates Agreement with Bristol Myers Squibb to Advance their Clinical Stage Immuno-Oncology Collaboration
8 April 2021 - - UK-based oncology company PsiOxus Therapeutics, Ltd has inked an updated agreement to advance its clinical collaboration with US-based pharmaceutical company Bristol Myers Squibb (NYSE: BMY) to evaluate the safety, tolerability, and preliminary efficacy of PsiOxus' tumor re-engineering platform, in combination with Bristol Myers Squibb's PD-1 immune checkpoint inhibitor Opdivo (nivolumab) to treat a range of tumor types in late-stage cancer patients, the company said.

The first stage of this collaboration combined Bristol Myers Squibb's Opdivo with PsiOxus' enadenotucirev in the Phase 1 SPICE study to determine the safety and tolerability of combining these two agents, and to optimise the combination intravenous dosing regimen.

The revised collaboration announced TODAY will build upon the initial study data and will combine Opdivo with PsiOxus' NG-641.

NG-641, is a tumor re-engineering product using PsiOxus' proprietary Tumor-Specific Immuno-Gene Therapy (T-SIGn) platform based upon the enadenotucirev vector.

NG-641 is a systemically administered product that encodes for the tumor selective delivery of an anti-FAP / anti-CD3 bispecific, interferon alpha, CXCL9 and CXCL10.

Fibroblast Activating Protein is selectively upregulated on the cancer associated fibroblasts that play an important role in the immune suppressive tumor microenvironment found in many stromally dense tumors that are refractory to checkpoint inhibitors.

Using a bispecific to drive T-cell mediated killing of CAF is designed to remove stroma and thereby reduce immune suppression within the tumor.

A combination of NG-641 and a checkpoint inhibitor such as Opdivo may thus provide an optimal treatment strategy for certain stromally dense tumors.

Opdivo is designed to uniquely harness the body's own immune system to help restore anti-tumor immune response.

By harnessing the body's own immune system to fight cancer, Opdivo has become an important treatment option across multiple cancers. Opdivo is a registered trademark of Bristol Myers Squibb.

Under the terms of this agreement, PsiOxus will be responsible for conducting the Phase 1 study with patient recruitment expected to start in 3Q21.

PsiOxus aims to lead the world in tumor re-engineering, delivering medicines of significant benefit to patients with cancer.

Its focus is on discovering and developing innovative transgene-based treatments for solid tumors using our proprietary, intravenously administered T-SIGn virus platform.

The compnay's portfolio comprises differentiated products that are all delivered systemically but act locally within the tumor.


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