EyeBio Appoints Industry Leaders to Executive Team
7 March 2023 - - UK-based privately held ophthalmology biotechnology company Eyebiotech Ltd. (EyeBio) has made several appointments to its executive team, featuring prominent industry leaders who are highly skilled in the development of multi-specific antibodies and ophthalmic drugs, the company said.

The company also announced details on Restoret, the first asset in a diversified pipeline of multi-specific agonist antibodies.

These developments establish the foundation to pursue the company's mission: to protect, restore, and improve vision for people who are underserved by available eye disease therapies.

EyeBio announced the following appointments to the senior leadership team:
Anthony P. Adamis, M.D., has been appointed chief scientific officer.

Dr. Adamis, who co-founded EyeBio in 2021 and Eyetech in 2002 with Dr. Guyer, previously served as senior vice president of Product Development and Development Innovation at Genentech, a member of The Roche Group.

Over the course of his career, he has led development programs in multiple therapeutic areas and has overseen 25 US Food and Drug Administration approvals, the most recent of which was faricimab, a novel anti-VEGF anti-Ang-2 bi-specific antibody for treating neovascular age-related macular degeneration and diabetic macular edema.

In addition to Dr. Adamis, EyeBio announced senior leadership appointments that further expand its international team of executives and investors with a track record for developing ground-breaking ophthalmology therapies:

Loni Da Silva, chief regulatory officer, brings extensive ophthalmology regulatory leadership experience and led the first retinal drug approval (Macugen);

Frances Betts, global head, clinical operations, has recruited thousands of patients into more than 20 ophthalmology clinical trials;

Mike Davies, chemistry, manufacturing, and control lead, drug development, led protein sciences for the development of bispecific antibodies at F-Star Therapeutics; and

Eric Ng, Ph.D., senior vice president, biology, developed novel therapeutics and animal models in ophthalmology as an Associate Professor at Harvard University.

These individuals join EyeBio's established team, which includes:

Dr. Guyer, Co-Founder, CEO, and president, co-founded Eyetech and Iveric Bio and brings expansive medical, drug development, and commercial experience in ophthalmology;

Sarah Milsom, chief operating officer, brings experience in life sciences strategy, development, and commercialization;

Jonathan Prenner, M.D., chief medical officer, is a noted retinal specialist, researcher, and biotech adviser; and

Paul Stephens, senior vice president, CMC and drug discovery, previously oversaw the transition of novel biologic entities from research to development at UCB Pharma.

Restoret is a tri-specific Wnt agonist antibody designed to address urgent unmet medical need in patients with back-of-the-eye diseases.

The result of a breakthrough in molecular design, Restoret will enable the clinical translation of the extensively studied Wnt pathway for the first time in the eye.

Since the discovery that Wnt genes code for proteins that drive normal development and maintenance of the blood-retinal barrier, the Wnt pathway has been a focus of many top research institutes.

Published research has shown that Wnt signaling in the retina plays a central role in the maintenance of vascular integrity, and defects in Wnt signaling cause retinal vascular leakage.

A mimetic of norrin, which is the natural Wnt ligand in the eye, Restoret has demonstrated efficacy in preclinical ophthalmic models, including validation in genetic models.

The EyeBio team plans to file for clinical trial authorizations to enable a global Phase 1b/2 clinical trial of Restoret in the second quarter of 2023.

EyeBio has also in-licensed a second bispecific agonist antibody asset for the treatment of retinal diseases, with a separate and complementary mechanism of action to Restoret.

These assets signal a diverse pipeline that leverages a core strength in developing multi-specific antibodies and intravitreal retinal therapies.

Eyebiotech Ltd. (EyeBio) is a privately held ophthalmology biotechnology company dedicated to developing and delivering a new generation of therapies to protect, restore, and improve vision in patients with sight-threatening eye diseases.

Founded in August 2021 by David Guyer, M.D., and Anthony P. Adamis, M.D., EyeBio has a leadership team composed of serial disruptors in ophthalmology drug development.

With operations in the United States and the United Kingdom, EyeBio is building and advancing a pipeline of ocular therapies that combine scientifically robust targets with innovative translational approaches.

EyeBio was seeded and created by SV Health Investors and raised a USD 65m series A in February 2022 led by SV Health Investors, alongside Samsara BioCapital and Jeito Capital, with additional financial backing from MRL Ventures.