18 July 2023 - - US-based TheracosBio said that Brenzavvy (bexagliflozin), an FDA-approved oral sodium-glucose cotransporter 2 (SGLT2) inhibitor, is now available by prescription through the Mark Cuban Cost Plus Drug company, PBC (Cost Plus Drugs).

A 30-day supply is available from Cost Plus Drugs for USD 47.85 plus shipping and handling.

BRENZAVVY is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

BRENZAVVY is not recommended for patients with type 1 diabetes mellitus and may increase the risk of diabetic ketoacidosis in these patients.

BRENZAVVY is available as 20 mg oral tablets recommended to be taken once daily, in the morning with or without food.

BRENZAVVY is contraindicated in patients who are hypersensitive to bexagliflozin or any other ingredient in the BRENZAVVY tablet and is not indicated for the treatment of type 2 diabetes in patients who are receiving dialysis.

The most common side effects of taking BRENZAVVY include female genital mycotic infections, urinary tract infections, and changes in urination, but more serious side effects are possible (see below, Important Safety Information about BRENZAVVY).

BRENZAVVY treatment can be initiated in adults with type 2 diabetes with an estimated glomerular filtration rate greater than or equal to 30 mL/min/1.73 m2. Patients with eGFR between 30 and 59 mL/min/1.73 m2 are said to be in stage 3 chronic kidney disease.

According to the US Centers for Disease Control and Prevention, more than 33m Americans have type 2 diabetes, which means their bodies don't use insulin correctly and as a result their blood sugar levels are too high.

While some people can control their blood sugar levels with exercise and a healthy diet, others may need additional help to achieve good blood sugar (glycemic) control.

SGLT2 inhibitors are a class of prescription medicines that lower blood sugar by causing the kidneys to release sugar from the body in the urine.

Phase 3 clinical studies have shown BRENZAVVY significantly reduces hemoglobin A1c and fasting blood sugar after 24 weeks, either as a monotherapy, in combination with metformin or as an add-on to standard-of-care treatment consisting of a variety of regimens, including metformin, sulfonylureas, insulin, DPP4 inhibitors or combinations of these agents.

Although BRENZAVVY is not approved for weight or blood pressure reduction, modest decreases in both weight and blood pressure have been observed in the clinical program.

TheracosBio develops novel therapeutics for diseases with significant societal impact. The mission of TheracosBio is to expand access to new medications for patients with common diseases.

The Mark Cuban Cost Plus Drug company, PBC aims to fundamentally change the way the pharmaceutical industry operates.

As a public-benefit corporation, its social mission of improving public health is just as important as the bottom line. Cost Plus Drugs transparently charges a standard markup on every drug it sells.

The costplusdrugs.com online pharmacy launched in January 2022 now carries over 1,000 generic and brand prescription products, delivered by mail to thousands of happy customers every day.