11 May 2023 - - US-based contract research organization Worldwide Clinical Trials has partnered with Every Cure, a nonprofit organization that unlocks new, often undiscovered uses for existing approved drugs by leveraging data, artificial intelligence, and efficient clinical trials, the company said.

Through this new partnership, Worldwide will serve as Every Cure's clinical trial and drug development partner.

The CRO will use its clinical development and rare disease expertise to assist in identifying links between rare diseases and generic drugs on the market all facilitated through the nonprofit's comprehensive, open-source database of drug-repurposing opportunities.

Once links and drug targets are identified and validated, Worldwide will run clinical trials for Every Cure with expedited timelines and a goal to unlock the full potential of existing medications to treat every disease possible and help rare disease patients around the world.

Every Cure is on a mission to alleviate suffering for the 300 m people globally who are battling diseases with no approved treatments.

The nonprofit launched in 2022 in partnership with the Clinton Global Initiative to scale up an innovative "drug-repurposing" approach to identify treatments for rare diseases generally considered to be a disease that affects fewer than 200,000 people in the United States or 5 in 10,000 people in the European Union at any given time, with small and geographically widespread patient populations.

Affecting these patient populations are the more than 9,000 diseases that have no approved treatment, which drives Every Cure's goal to discover the full potential of the estimated 3,000 drugs currently on the market.

Every Cure was co-founded by Dr. David Fajgenbaum, Dr. Grant Mitchell, and Tracey Sikora in 2022.

During Dr. Fajgenbaum's third year of medical school, he became critically ill with Castleman disease (CD) and was hospitalized in critical condition for months. This experience launched his mission to find treatments to save his own life and others.

Dr. Fajgenbaum's team discovered an overactive pathway in his immune system and began testing a 25-year-old drug, which had never been used for CD, to block it. He has now been in remission for more than nine years.

Worldwide Clinical Trials (Worldwide) is a leading full-service global contract research organization that works in partnership with biotechnology and pharmaceutical companies to create customized solutions that advance new medications from discovery to reality.

Its capabilities include bioanalytical laboratory services, Phase I-IV clinical trials, and post-approval and real-world evidence studies.

The company's team of 3,000+ professionals spans 60+ countries.

Every Cure is a nonprofit organization dedicated to unlocking the full potential of every existing medicine to treat every disease possible.