OncoPep is developing the adoptive T cell therapy as part of a licensing agreement with MANA Therapeutics. MANA's EDIFY platform is specifically designed to train T cells to target multiple tumor associated antigens, harnessing the patient's immune system for an approach that targets a broader set of antigens expressed by the tumor.
In this collaboration, a patient's T cells will be trained ex vivo with EDIFY to target the antigens, XBP1, CD138 and CS1, which are highly over-expressed in multiple myeloma and other solid tumors.
OncoPep's lead therapeutic cancer vaccine candidate, PVX-410, is also designed to train T cells to target XBP1, CD138 and CS1 and could potentially be used in combination with the adoptive T cell therapy.
This new adoptive T cell therapy approach has the potential to provide more persistent and durable control over tumor cell growth and could prevent the progression of cancer and improve quality of life for patients with multiple myeloma.
Multiple myeloma is a debilitating type of hematologic cancer that affects plasma cells. It is the second most common blood cancer, accounting for 13% of all hematologic cancers and 1% of all cancer deaths.
MM is characterized by a proliferation of malignant plasma cells, which may in turn interfere with the normal production of blood cells.
MM causes significant side effects, such as debilitating bone pain and fractures, anemia, leukopenia, thrombocytopenia, renal insufficiency and failure, hypercalcemia and increased chance of infection.
OncoPep is developing targeted immunotherapeutics to prevent the progression of cancer, prolong survival and restore the quality of life of patients. OncoPep's lead program is an investigational, multi-peptide therapeutic vaccine being evaluated in treating smoldering multiple myeloma.
TuHURA Biosciences acquires Kineta
Tyra Biosciences doses first patient in TYRA-300 Phase 2 study for bladder cancer
HUTCHMED gains China approval for ORPATHYS and TAGRISSO combination in lung cancer
Mabwell and Qilu Pharmaceutical enter licence agreement for Albipagrastim alfa for Injection
FDA approval streamlines access to Bristol Myers Squibb CAR T cell therapies
Biovica secures European patent for biomarker use in immuno-oncology
CARsgen Therapeutics' satri-cel NDA accepted by Chinese regulator
Scancell expands Phase 2 SCOPE trial with new intradermal dosing arm for iSCIB1+
Telix Pharmaceuticals delivers first commercial doses from Belgian manufacturing hub
Innovent presents mazdutide Phase 3 clinical study results at ADA 85th Scientific Sessions
Hoth Therapeutics reports positive interim results for HT-001 topical therapy
Aiforia Technologies launches CE-IVD marked AI solution for breast cancer diagnostics
Stockholders approve proposed merger of TuHURA Biosciences and Kineta
Sarclisa recommended for EU approval in newly diagnosed transplant-eligible multiple myeloma