Therapy Areas: Oncology
OncoPep Strengthens Pipeline with Addition of Multi-Tumor Antigen Adoptive T Cell Therapy
15 October 2020 - - US-based OncoPep, Inc has inked a licensing agreement with MANA Therapeutics for use of its EDIFY platform for the development of an autologous multi-tumor antigen adoptive T cell therapy for the treatment of multiple myeloma and solid tumors, as an additional T cell focused immunotherapeutic for its product pipeline, the company said.

OncoPep is developing the adoptive T cell therapy as part of a licensing agreement with MANA Therapeutics. MANA's EDIFY platform is specifically designed to train T cells to target multiple tumor associated antigens, harnessing the patient's immune system for an approach that targets a broader set of antigens expressed by the tumor.

In this collaboration, a patient's T cells will be trained ex vivo with EDIFY to target the antigens, XBP1, CD138 and CS1, which are highly over-expressed in multiple myeloma and other solid tumors.

OncoPep's lead therapeutic cancer vaccine candidate, PVX-410, is also designed to train T cells to target XBP1, CD138 and CS1 and could potentially be used in combination with the adoptive T cell therapy.

This new adoptive T cell therapy approach has the potential to provide more persistent and durable control over tumor cell growth and could prevent the progression of cancer and improve quality of life for patients with multiple myeloma.

Multiple myeloma is a debilitating type of hematologic cancer that affects plasma cells. It is the second most common blood cancer, accounting for 13% of all hematologic cancers and 1% of all cancer deaths.

MM is characterized by a proliferation of malignant plasma cells, which may in turn interfere with the normal production of blood cells.

MM causes significant side effects, such as debilitating bone pain and fractures, anemia, leukopenia, thrombocytopenia, renal insufficiency and failure, hypercalcemia and increased chance of infection.

OncoPep is developing targeted immunotherapeutics to prevent the progression of cancer, prolong survival and restore the quality of life of patients. OncoPep's lead program is an investigational, multi-peptide therapeutic vaccine being evaluated in treating smoldering multiple myeloma.


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