Therapy Areas: Infectious Diseases
Emergex Completes Preclinical Testing of its Lead 'Set-Point' Vaccine Candidate for Dengue Fever and Other Flaviviruses
11 December 2019 - - UK-based biotechnology company Emergex Vaccines Holding Ltd has completed preclinical testing of its lead vaccine candidate for Dengue Fever, the company said.

The vaccine construct, which comprises Nature's gene-chip peptides bound to a quantum cluster gold nanoparticle delivery system, was shown to have an excellent safety profile in a repeat dose GLP (Good Laboratory Practice) grade toxicology study using a standard industry model.

No adverse reactions were seen at any dose level. This completes Emergex's preclinical data package, allowing movement into the clinical phases of development.

This work builds upon previous preclinical work including GLP toxicology testing of the gold nanoparticle, which will form the base for all of Emergex's vaccines and efficacy studies of the vaccine candidate.

In addition to providing disease prophylaxis to Dengue Fever, this vaccine candidate may also provide immunity to other flaviviruses including Zika and Yellow Fever, as the peptides chosen in the vaccine construct are highly conserved amongst flaviviruses.

Emergex is developing vaccines that reduce morbidity against existing and newly emerging infectious outbreaks for use by governments (National Health Services) and non-governmental organisations. It is also forming partnerships with pharmaceutical companies to generate both milestone and future royalty revenue streams on sales of vaccines.

Dengue Fever is a mosquito-borne viral infection prevalent in tropical and semi tropical parts of the world. In recent decades it has spread and TODAY approximately half the world's population is at risk of contracting it. Patients usually present with flu like symptoms, such as a headache and fever.

However, Severe Dengue (Dengue Haemorrhagic Fever), can occur in up to 5% of cases and is a leading cause of hospitalisation and death among children in Dengue-affected regions.
References

Emergex Vaccines Holdings Ltd., a UK-based biotechnology company headquartered in Abingdon, UK, is pioneering the development of 'set-point' vaccines to address some of the world's most immediate health threats such as Dengue Fever, Zika, Ebola, pandemic flu and serious intra-cellular bacterial infections.

These 'set-point' vaccines modify the initial immune status of recipients in a way that 'primes' their immune systems to recognise subsequent infectious agents much like a natural infection would do, preventing an acute or severe manifestation of the disease.
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