Therapy Areas: Devices
Sherlock Biosciences Launches Innovation Lab to Develop COVID-19 Diagnostics with USD 7.5m Grant from Open Philanthropy
22 May 2020 - - Open Philanthropy is advancing USD 7.5m in grant funding to launch US-based diagnostic testing specialist Sherlock Biosciences' Sherlock Innovation Lab and accelerate the development of Sherlock's at-home COVID-19 diagnostic utilising its INSPECTR platform, the company said.

In 2019, Open Philanthropy awarded Sherlock a USD 17.5m non-dilutive grant to develop its SHERLOCK platform for use at home, hospitals and in the field. As part of that grant, and with the onset of the global pandemic, this advance from Open Philanthropy will also support the development of INSPECTR to meet the need for increased testing capacity worldwide.

Leveraging the power of Synthetic Biology, Sherlock's INSPECTR (Internal Splint-Pairing Expression Cassette Translation Reaction) platform enables the creation of an instrument-free, handheld diagnostic test similar to that of an at-home pregnancy test that can be applied across multiple diseases and in a variety of settings.

With the launch of the Sherlock Innovation Lab in Cambridge, the company is currently hiring industry and academic experts in synthetic biology to focus exclusively on scaling INSPECTR for at-home and low-resource environments.

Numerous non-profit organizations are participating in the effort to deploy talent, including MassBio, MassMEDIC and Gloucester biotechnology Academy.

By tapping into the vast expertise of their membership and broader network, Sherlock aims to immediately bring 10-15 molecular diagnostic experts into its second facility to focus on the development of the company's INSPECTR-based COVID-19 solution.

In addition to INSPECTR, the Sherlock Innovation Lab will focus on advancing the company's SHERLOCK platform, a CRISPR-based method to detect and quantify specific genetic sequences.

Earlier this month, the company received Emergency Use Authorization from the US Food and Drug Administration for its Sherlock CRISPR SARS-CoV-2 kit, the first FDA-authorized use of CRISPR technology.

A Synthetic Biology-based molecular diagnostic platform, INSPECTR is licensed exclusively from the Wyss Institute of Harvard University.

INSPECTR can be programmed to distinguish targets based on a single nucleotide without an instrument and at room temperature.

When INSPECTR's synthetic biosensors detect the presence of a nucleic acid target, a reporter protein is produced. This protein output can be designed to generate a signal tailored to any medium, providing a simple diagnostic readout.

This novel approach enables the rapid development of molecular diagnostic tests that are low-cost, easy-to-use and broadly applicable, making it an ideal diagnostic testing solution for low-resource and at-home environments.

Sherlock Biosciences is dedicated to making molecular diagnostics better, faster and more affordable through Engineering Biology platforms.

The company is developing applications of SHERLOCK, a CRISPR-based method to detect and quantify specific genetic sequences, and INSPECTR, a Synthetic Biology-based molecular diagnostics platform that is instrument-free.

SHERLOCK and INSPECTR can be used in virtually any setting without complex instrumentation, opening up a wide range of potential applications in areas including precision oncology, infection identification, food safety, at-home tests, and disease detection in the field.

In May 2020, the company received Emergency Use Authorization from the US Food and Drug Administration for its Sherlock CRISPR SARS-CoV-2 kit, the first FDA-authorized use of CRISPR technology.

Open Philanthropy identifies outstanding giving opportunities, makes grants, follows the results, and publishes its findings. Its mission is to give as effectively as it can and share its findings openly so that anyone can build on its work.

The Massachusetts Medical Device Industry Council (MassMEDIC), an organization of more than 300 manufacturers, suppliers, research institutions, and academic health centers, promotes the unique interests of the Bay State's growing and vibrant medical device sector.

Through a variety of programs, informational seminars, advocacy campaigns and other projects, MassMEDIC provides medical device manufacturers and suppliers with information on industry trends and regulatory policies and creates forums that allow members to exchange ideas and information on issues affecting the industry.

Gloucester biotechnology Academy is the educational entity within GMGI (Gloucester Marine Genomics Institute) that trains young adults to become entry-level lab technicians in the growing field of biotechnology.
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