The award was based on research and development milestones achieved by BioAxone.
CCM is a serious genetic disease where patients have a lifetime risk of brain hemorrhage from vascular malformations in the brain in which endothelial cells form single or multiple cystic brain lesions that leak and may cause seizure, hemorrhagic stroke, and neurological deficits.
Inherited cases of CCM are caused by mutation in one of the 3 CCM genes (CCM1, CCM2 and CCM3) and CCM loss of function results in the overactivation of ROCK2, the target of BA-1049 development.
In preclinical experiments BA-1049, a first-in-class oral inhibitor of Rho kinase 2 (ROCK2), has shown promise to repair the leaky endothelial cell barrier and potentially to reverse progression of disease. BioAxone is progressing key non-clinical IND enabling studies with this small molecule.
BioAxone BioSciences is developing innovative drugs to restore neurological function for patients with spinal cord injuries, vascular malformations in the central nervous system, and glaucoma.
Nuvalent commences NVL-655 phase 2 clinical trial in subjects with NSCLC and other solid tumours
GC Biopharma's GC1130A receives EMA Orphan Drug Designation
Guangzhou Fermion Technology's FZ008-145 IND application receives Chinese regulatory approval
Newron enrols 290 patients in schizophrenia study
Vistagen granted European patent for AV-101 to treat neuropathic pain
GenSight Biologics reports business and financial update
Alora Pharmaceuticals announces Relexxii commercial launch
IGC Pharma granted patent for Alzheimer's drug formulation
NRx Pharmaceuticals signs data agreement with Columbia University for IV Ketamine trials