Concert is conducting a multi-center, double-blind, randomized, placebo-controlled Phase 2a trial to evaluate the safety and efficacy of CTP-543 in adults with moderate-to-severe alopecia areata.
Alopecia areata is an autoimmune disorder in which the immune system attacks hair follicles, resulting in patchy or complete hair loss.
CTP-543 was discovered by applying Concert's deuterium chemistry technology to modify ruxolitinib, a drug which selectively inhibits Janus kinases 1 and 2 (JAK1 and JAK2) and is commercially available under the name Jakafi in the US for the treatment of certain blood disorders.
Ruxolitinib has been used to treat alopecia areata in academic settings, including an investigator-sponsored clinical trial, and has been reported to promote hair growth in individuals with moderate-to-severe disease.
Concert Pharmaceuticals focuses on applying its deuterated chemical entity platform to create novel medicines designed to address unmet patient needs.
The company's approach starts with approved drugs in which deuterium substitution has the potential to enhance clinical safety, tolerability or efficacy. Concert has a broad pipeline of innovative medicines targeting autoimmune and inflammatory diseases and central nervous systems disorders.
Innovent treats first cancer patient in Phase I clinical trial of Anti-OX40 Antibody
Mayne Pharma unveils Lexette (halobetasol propionate) foam 0.05% in the US plaque psoriasis market
US FDA posts warning letters to companies illegally selling more than 58 products
Parexel Appoints Former FDA Senior Executives to Global Regulatory Consulting Services
US Patent Issued for AXA Candidate AXA1125
Omeros Names Bumol to Board of Directors
Calliditas Therapeutics announces grant of ODD by US FDA for primary biliary cholangitis
Harmony Biosciences submits Pitolisant NDA with US FDA under priority review
Calliditas Therapeutics wins US FDA orphan drug designation for primary biliary cholangitis