The license agreement with the NRC grants Appili exclusive worldwide rights to develop and commercialize this tularemia vaccine.
ATI-1701 is based on research led by Dr. Wayne Conlan at the NRC. Conlan's team used genetic engineering to disable a previously virulent strain of F. tularensis and develop a live attenuated vaccine. Their research showed the genetically modified bacterium induced a strong immune response that triggers a protective immune response to F. tularensis.
Some of the development work for the vaccine is being funded by the Defense Threat Reduction Agency, part of the US Department of Defense, which recently announced a USD6.2 m, 5-year program to develop a tularemia vaccine.
Appili will conduct the preclinical and clinical testing required by the FDA to evaluate the safety of the ATI-1701 vaccine and to ensure it offers the desired protection against the bacteria for humans.
Appili is dedicated to identifying, acquiring, and advancing novel therapeutics for infectious disease.
Its pipeline includes three anti-infective programs: ATI-1501, a novel taste-masking technology applied in an oral suspension for the treatment for anaerobic infections, ATI-1503, a novel antibiotic targeting drug-resistant Gram-negative infections, and ATI-1701, a vaccine reducing the threat of tularemia bioterrorism.
MaaT Pharma reveals positive 18-month data for MaaT013 in GI-aGvHD
Innate Pharma advances Sanofi-developed NK cell engager to Phase 2 for blood cancer patients
Precision Epigenomics partners with TruDiagnostic
Illumina's GRAIL divestment plan receives EC approval
Soligenix receives orphan drug designation from FDA for active ingredient in SuVax
Candel Therapeutics granted FDA Orphan Drug Designation for CAN-2409 in pancreatic cancer treatment
Lipogems completes patient enrolment in ARISE I US FDA IDE study
Amylyx Pharmaceuticals' AMX0035 shows promising impact on Wolfram syndrome symptoms
Ondine Biomedical's Steriwave approved for use by HCA UK
Roche attains CE Mark for first companion diagnostic for HER2-low metastatic breast cancer
Cadrenal Therapeutics' tecarfarin receives US FDA Orphan Drug Designation
BioCity Biopharma's BC2027 Phase one study IND application receives US FDA approval
Seres Therapeutics completes patient enrollment for SER-155 Phase 1B trial
Syros receives Fast Track Designation from FDA for tamibarotene in AML