Policy & Regulation
Akoya Biosciences Collaborates with UCSF Helen Diller Family Comprehensive Cancer Center
31 July 2020 - - US-based biotechnology company Akoya Biosciences, Inc has forged a collaboration with UCSF Helen Diller Family Comprehensive Cancer Center, the company said.

Scientists at UCSF Helen Diller Family Comprehensive Cancer Center have chosen Akoya's Phenoptics multiplex immunofluorescence platform for developing predictive and prognostic biomarkers, particularly for use in selecting the most effective neoadjuvant and adjuvant immunotherapies for patients with early breast cancer. 

At UCSF, this collaboration will be led by Michael Campbell, PhD, and Laura Esserman, MD, MBA.

Dr. Campbell is an immunologist who has worked in partnership with Dr. Esserman to better understand how to optimise immunotherapy. He is driving the work on the Phenoptics platform to develop predictors of response to the immuno-oncology drug combinations, and to use these insights to develop more effective combinations.

Together they are working both on high risk invasive breast cancer and high-risk ductal carcinoma in situ.

Dr. Esserman is a professor in the departments of Surgery and Radiology who co-leads the breast oncology program at the UCSF Helen Diller Family Comprehensive Cancer Center, and is the Principal Investigator of the I-SPY Trials, sponsored by the Quantum Leap Healthcare Collaborative.

Following extensive evaluation of biomarker testing methods, Dr. Esserman and her team have standardized biomarker discovery and development efforts on the Phenoptics platform to measure as many as six markers at a time on a single pathology slide using multiplex immunofluorescence.

The Phenoptics platform is the chosen platform for the I-SPY Trials.

Immunotherapies harness the immune system to fight cancer and are increasingly being used in the early high-risk setting. The partnership's goals are to make these therapies more effective and to understand the immune response, key to making them work for more patients.

There is an urgent need for biomarkers that more accurately predict which patients will respond to a particular therapy.

Multiplex immunofluorescence preserves critical spatial data about cell proximity and interaction in the tumor microenvironment, with the potential to provide higher predictive power compared to other biomarker approaches.

Akoya's Phenoptics platform provides an end-to-end solution for discovery research and clinical trials with the reproducibility, sensitivity and throughput needed to develop new biomarkers and has become the standard for biomarker-based clinical trials and translational research.

The I-SPY TRIAL (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis) was designed to rapidly screen promising experimental treatments and identify those most effective in specific patient subgroups based on molecular characteristics (biomarker signatures).

The trial is a unique collaborative effort by a consortium that includes the Food and Drug Administration, industry, patient advocates, philanthropic sponsors, and clinicians from more than 20 major US cancer research centers.

Under the terms of the collaboration agreement, Quantum Leap Healthcare Collaborative is the trial sponsor and manages all study operations.

The University of California, San Francisco is focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. 

UCSF Health, which serves as UCSF's primary academic medical center, includes top-ranked specialty hospitals and other clinical programs, and has affiliations throughout the Bay Area. Learn more at ucsf.edu, or see our Fact Sheet.

Quantum Leap Healthcare Collaborative is a 501(c) (3) charitable organization established in 2005 as a collaboration between medical researchers at University of California, San Francisco and Silicon Valley entrepreneurs.

Akoya Biosciences, The Spatial Biology company, offers the solutions for high-parameter tissue analysis from discovery through clinical and translational research, enabling the development of more precise therapies for immuno-oncology and other drug development applications.

The company has two platforms that empower investigators and researchers to gain a deeper understanding of complex diseases such as cancer, and other immune system or neurological disorders.

The CODEX system is the only benchtop platform that can efficiently quantify more than 40 markers and is ideally suited for biomarker discovery. The Phenoptics platform is the only end-to-end multiplexed immunofluorescence solution with the robustness and high throughput necessary for translational research and clinical trials.
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