Both JAK inhibitors met the primary efficacy endpoint in improving hair regrowth on the scalp relative to baseline at week 24 (33.6 points and 49.5 points for JAK3 and TYK2/JAK1, respectively) as measured by the Severity of Alopecia Tool score (100 point scale).
The findings were presented during a Late-Breaking News session at the 27th European Academy of Dermatology and Venereology Congress in Paris, France.
Based on the totality of the data and the emerging clinical profiles, the investigational JAK3 inhibitor, which was recently granted Breakthrough Therapy designation from FDA for alopecia areata, is advancing to the next phase of development for moderate to severe AA and will continue to be evaluated for rheumatoid arthritis, Crohn's disease and ulcerative colitis.
PF-06700841 will continue to be evaluated for psoriasis, CD and UC.
This Phase 2a, randomised, double-blind, multicenter study evaluates the efficacy, safety, and tolerability of PF-06651600 and PF-06700841 compared to placebo in patients with moderate to severe AA. Patients were randomized 1: 1: 1 to receive: PF-06651600 (200 mg once daily [QD] for four weeks, followed by 50 mg QD for 20 weeks), or PF-06700841 (60 mg QD for 4 weeks, followed by 30 mg QD for 20 weeks), or placebo.
The study found that the placebo-adjusted mean (95% CI) in SALT change from baseline scores at Week 24 were 33.6 points (21.4, 45.7), (P
GSK releases decade-long data on Shingrix efficacy
GSK announces positive EAGLE-1 results for gepotidacin in gonorrhoea treatment
Boehringer Ingelheim reports strong growth in 2023 and accelerates late-stage pipeline
Charles River Laboratories launches AMAP to reduce animal testing reliance
PureTech completes enrollment in Phase 2b ELEVATE IPF trial for LYT-100
Cybin secures additional US patent for CYB003 breakthrough therapy programme
UroGen's UGN-103 IND accepted by FDA for bladder cancer treatment
Biophytis reinforces obesity IP with new patent application
MaaT Pharma reveals positive 18-month data for MaaT013 in GI-aGvHD
Fusion Antibodies plc secures contract for OptiPhage library development
Innate Pharma advances Sanofi-developed NK cell engager to Phase 2 for blood cancer patients