Policy & Regulation
Genentech Phase III Study of Tecentriq (Atezolizumab) and Cotellic (Cobimetinib) Combination Fails to Meet Primary Endpoint
15 May 2018 - - South San Francisco, California-based biotechnology company Genentech's Phase III IMblaze370 study evaluating the combination of Tecentriq (atezolizumab) and Cotellic (cobimetinib) did not meet its primary endpoint of overall survival compared to regorafenib, the company said.
The study evaluated the combination in people with difficult-to-treat, locally advanced or metastatic colorectal cancer whose disease progressed or who were intolerant to at least two systemic chemotherapy regimens.
The results from IMblaze370 were consistent with this prior monotherapy experience, showing that treatment with Tecentriq alone did not provide a meaningful clinical benefit compared to regorafenib in this patient population.
Safety for the combination of Tecentriq and Cotellic appeared to be consistent with the known safety profiles of the individual medicines, and no new safety signals were identified with the combination.
IMblaze370 is a Phase III, multi-center, open-label, three-arm, randomized study in people with difficult-to-treat locally advanced or metastatic colorectal cancer who have received at least two prior regimens of chemotherapy for metastatic disease.
The study compares regorafenib, a standard of care therapy in this setting, to Cotellic plus Tecentriq and Tecentriq monotherapy.
Genentech, a member of the Roche Group (SIX: RO) (OTCQX: RHHBY), discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions.


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