Policy & Regulation
10x Genomics Launches New Single Cell Solution Focused on DNA
17 April 2018 - - Pleasanton, California-based sequencing specialist 10x Genomics has launched the Chromium Single Cell CNV Solution, a scalable and easy-to-use technology for rapid and parallel profiling of single cell genomes, the company said.
This new solution is the first to be built upon their new technology advancement for generating cell beads and gel beads (CBGBs).
The company's solution overcomes the limitations of current commercial methods for copy number variation (CNV) profiling, including either manual manipulation of single cells or bulk sequencing, and enables preparation of hundreds to thousands of single cells for CNV profiling within minutes on either the Chromium Controller or the Chromium Single Cell Controller.
The Chromium Single Cell CNV Solution powers a broad range of research opportunities, which include revealing tumor heterogeneity, characterizing somatic mosaicism of neurons, as well as authenticating cell line identity and clonal purity. 
Of crucial importance to cancer research, the solution provides more detailed insight into the clonal structure of cancer samples, including spatial distribution across tumor slices and longitudinal changes. This high-resolution view of cancer heterogeneity may be used to trace clonal evolution during tumor growth, treatment response, and development of drug resistance.
The solution also includes a comprehensive software suite from 10x Genomics to rapidly analyze and visualise large single cell CNV experiments.
The Cell Ranger DNA analysis pipeline provides a turnkey solution for single cell CNV calling and clustering. The Loupe scDNA Browser provides a powerful and easy-to-use tool for inspecting and interrogating genomic regions and cell clusters.
10x Genomics provides an innovative genomics platform that dramatically upgrades the capabilities of existing sequencing technologies through a combination of new microfluidic science, chemistry, and bioinformatics.


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